Selected Publications

Zahavi E., Maimon R., Perlson E. (2017). Spatial-Specific Functions in Retrograde Neuronal Signaling. Traffick. 2017 Apr 10. doi: 10.1111/tra.12487
 
Naftelberg S., Ast G., Perlson E. (2017). Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases. Neural Regen Res 12(4):534-537
  
Rotem N., Magen I., Ionescu A., Gershoni-Emek N., Altman T., Gradus T., Pasmanik-Chor M., Willis DE., Ben-Dov IZ., Horenstein E., Perlson E. (2017).  ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS models. Sci Rep. 2017 Mar 16;7:44500. doi: 10.1038/srep44500.
  

Naftelberg S., Abramovitch Z, Gluska S, Yannai S, Joshi Y, Donyo M, Ben-Yaakov K, Gradus T, Zonszain J, Farhy C, Ashery-Padan R, Perlson E, Ast G. (2016). Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia. PLoS Genet. 2016 Dec 20;12(12):e1006486. doi: 10.1371/journal.pgen.1006486.

Gluska S, Chein M, Rotem N, Ionescu A, Perlson E. (2016). Tracking Quantum-Dot labeled neurotropic factors transport along primary neuronal axons in compartmental microfluidic chambers. Methods Cell Biol. 2016;131:365-87. doi: 10.1016/bs.mcb.2015.06.016. 

Ionescu, A., Zahavi, E., Gradus, T., Ben-Yaakov, K., & Perlson, E. (2015). Compartmental microfluidic system for studying muscle–neuron communication and neuromuscular junction maintenance. European Journal of Cell Biology.  
 
Gershoni-Emek, N., Mazza, A., Chein, M., Gradus-Pery, T., Xiang, X., Li, K., Sharan R., Perlson, E. (2015). Proteomic analysis of dynein-interacting proteins in Amyotrophic Lateral Sclerosis synaptosomes reveals alterations in the RNA-binding Protein Staufen1. Mol Cell Proteomics. pii: mcp.M115.049965
 
Bornstein, B., Zahavi, E., Gelley, S., Zoosman, M., Yaniv, S., Fuchs, O., Porat Z, Perlson E, Schuldiner, O. (2015). Developmental Axon Pruning Requires Destabilization of Cell Adhesion by JNK Signaling. Neuron, 926-940. 
 
Bauer, A., Nolden, T., Nemitz, S., Perlson, E., & Finke, S. (2015). A Dynein Light Chain 1 Binding Motif in Rabies Virus Polymerase L Protein Plays a Role in Microtubule Reorganization and Viral Primary Transcription. J. Virol. Journal of Virology, 9591-9600. 
 

Zahavi EE., Ionescu A., Gluska S., Gradus T., Ben-Yaacov K., Perlson E. (2015) Spatial Aspects of GDNF Functions Revealed in a Compartmentalized Microfluidic Neuromuscular Co-Culture System. J Cell Sci. pii: jcs.167554

Bauer A., Nolden T., Römer-Oberdörfer A., Gluska S.,  Perlson E., and FinkeS.  Post-Replicative Glycoprotein Dependent Bi-Directional Rabies Virus Transport in Dorsal Root Ganglion Neurons. J of Virology. pii: JVI.02254-14.

Dadon- Nachum M., Ben-Yaacov K., Ben- Zur T. Barhum Y., Yaffe D. Perlson E.   and Offen D. (2014). Transplanted modified muscle progenitor cells expressing a mixture of neurotrophic factors delay disease onset and enhance survival of ALS model SOD1 mice. J of Molecular Neuroscience.

Gluska S., Zahavi E., Chein M., Gradus T, Bauer A., Finke S. and Perlson E.  (2014). Rabies Virus Hijacks and Accelerates the p75NTR Retrograde Axonal Transport Machinery. Plos Pathogen. 10(8):e1004348. doi: 10.1371/journal.ppat.1004348.

Gershoni-Emek, N., Zahavi EE., Gluska S., Slobodskoy Y and Perlson E. (2014)The Molecular Communication Mechanism of Neuron Survival and Synapse Maintenance. (Book chapter), In press.

Castle M, Perlson E, Holzbaur EL, Wolf JH, (2013)  "Long-Distance Axonal Transport of AAV9 is Driven by Dynein and Kinesin-2 and is Trafficked in a Highly Motile Rab7-Positive Compartment". Mol Therapy. 22(3):554-66.

Perlson E, Hendricks AG, Wilson MH, Lazarus JE, Ben-Yaacov K, Zhang X, Xiang X, Holzbaur EL. (2013). “Dynein interacts with NCAM180 to tether and stabilize synaptic microtubules”. JBC. 27;288(39):27812-24

Lilo E, Wald S, Solmesky L, Ben Yaakov K, Gershoni- Emek N, Gotkine M, Karosis D, Bulvik S, Perlson E and Weil M. (2013). “Characterization of human sporadic ALS biomarkers in the familial transgenic mSOD1G93A mouse model”. Hum Mol Genet. 22(23):4750-5.

Perlson, E., Maday, S., Fu, M., Moughamian, A., Holzbaur, E.  (2010) Retrograde Axonal Transport: Pathways To Cell Death? Trends in Neuroscience. 33 (7), 335-44.

Hendricks, A.*,Perlson, E.*, Ross, J., * Schroeder, H., Tokito, M., Holzbaur, E. (2010) Motor coordination via tug-of war mechanism drives bidirectional vesicle transport. Current Biology. 20(8), 697-702.   

Perlson, E., Jeong, GB., Ross, JL., Dixit, R., Wallace, KE., Kalb, RG., Holzbaur, EL. (2009) A Switch in Retrograde Signaling From Survival to Stress Leads to Rapid Onset Neurodegeneration. The Journal of Neuroscience 29(31);9903-9917.

Perlson, E., Holzbaur, EL. (2007)The Role of Molecular Motors in Axonal Transport. "Protein Trafficking in the Neuron" Andrew Bean editor. Elsevier Publishing. (Book chapter). 

Perlson, E., Hanz, S., Ben-Yaakov, K., Segal-Ruder, Y., Seger, R., Fainzilber, M. (2005) Vimentin dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron 45(5):715-726.

Perlson, E., Medzihradszky, KF., Darula, Z., Munno, DW., Syed, NI., Burlingame, AL., Fainzilber, M. (2004) Differential proteomics reveals multiple components in retrogradely transported axoplasm after nerve injury. Mol Cell Proteomics. 3(5): 510-20.

Perlson, E., Hanz, S., Medzihradszky, K.F., Burlingame, A.L., Fainzilber, M., (2004) From snails to sciatic nerve: retrograde injury signaling from axon to soma in lesioned neurons. J Neurobiol. 58:287-94. (Dev Biology).

Hanz, S., Perlson, E., Willis, D., Huerta, J.J., Massarwa, R., Zheng, JQ, Kohler, M, van Minnen J., Koltzenburg, M., Twiss J.L., Fainzilber M., (2003) Axoplasmic importins enable retrograde injury signaling in lesioned nerve. Neuron 40:1095-104.

 

Dr. Eran Perlson, head of the Mary Shapiro Kantor Laboratory, Dept. of Physiology and Pharmacology, Sackler Faculty of Medicine. Tel Aviv University