Contact Details

      

 

Dr. Eran Perlson

Head of the Mary Shapiro Kantor Laboratory
Dept. of Physiology and Pharmacology
Sackler Faculty of Medicine, Room 605
Tel Aviv University
Ramat Aviv, Tel Aviv 69978, Israel
Tel office:+972-3-6408743
Tel lab:+972-3-6409109
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The Role of Local Protein Synthesis in Axonal/Neuromuscular Junction Maintenance

We aim to elucidate mechanisms of local protein synthesis in distal axons and at the neuormuscular junction and to understand their role in maintaining the structural and functional integrity of the synapse.

Schematic Overview of the Anterograde and Retrograde Regulation of Spatiotemporal Signaling in the Motor Unit

We are interested in understanding the fundemental molecular communitcation mechanisms in motor neurons and how these are regulated by 1) Axonal transport of signaling cargos 2) Neurotrophin transmission and receptor dynamics 3) Retrograde transmission of local translation machinery and regulatory elements from muscles.  

Rabies virus hijacks and accelerates the p75 neurotrophine receptor retrograde axonal transport machinery

In order to arrive at the neuronal cell body and subsequently the CNS, rabies virus hijacks a fast route using the p75 neurotrophin receptor endosomal pathway. While relying on the p75 dependent path, Rabies virus manipulates the axonal transport machinery to migrate faster to the cell body. An alternative, slower path, may involve other Rabies receptors.

 

Dr. Eran Perlson, head of the Mary Shapiro Kantor Laboratory, Dept. of Physiology and Pharmacology, Sackler Faculty of Medicine. Tel Aviv University