Contact Details

Admin: Ms. Sara Ben Arie (This email address is being protected from spambots. You need JavaScript enabled to view it.)

Mail address: Prof. Roy Beck, (This email address is being protected from spambots. You need JavaScript enabled to view it.)

School of Physics and Astronomy, Tel-Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel

Office address: (1) Shenkar Physics (Map), Office 418, Phone: +972-3-6408477, Fax : +972-3-6429306

Labs: Center for Nanoscience and Nanotechnology, Rooms: 35, 21. Phone +972-3-6405702, Fax: + 972-3-6405590

Open Positions

Now recruiting students (Master, PhD) and post-docs from Biology, Physics, Chemistry and Engineering.Come and join a multi-disciplinary research lab at the interface between Physics and biology!

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Structure and Interaction of Intermediate FIlaments

Cross-polarized microscopy image of a neurofilament network in a quartz capillary. The network was self-assembled of recombinant NF-L protein. The nematic domain boundaries are a clear indication of the extended length scale of the ordered phase.

Expression and localization of fluorescent-tagged intermediate filaments

Complex lattice in transfected cells devoid of endogenous cytoplasmic intermediate filaments. The filaments are localized proximate to the cell center where they provide mechanical support to intracellular organelles.

Structural Transition in Myelin Membrane as Initiator of Multiple Sclerosis

Congratulation to Rona and the rest of team for the wonderful work published in JACS! In the paper we show that myelin membranes having the lipid composition previously found in multiple sclerosis,  structurally transition into inverted hexagonal phase. 

Neurofilaments function as pneumatic shock absorbers: compression response arising from disordered proteins

Congratulation  to Micha, Eti and the rest of team for the wonderful work published in PRL! In the paper we show how disordered proteins control the compression response and the mechanoelastic properties of neuronal cytoskeleton.  

Modern X-ray scattering studies of complex biological systems

Check out our recent review in Current Opinion in Biotechnoloy:   X-ray scattering is one of the most prominent structural characterization techniques in biology. The key advantage of X-ray scattering is its ability to penetrate and weakly interact with the bare studied materials. In addition, X-ray scattering does not require any tags, markers or modification to the sample under examination, and is not limited by the nature of the surrounding environment. The main handicapping limitation of X-ray scattering is the subject of particles polydispersity. However, the monodispersity in biological complexes and supra-molecular interactions makes them ideal for structural and interaction...

Biomolecules Supramolecular Assemblies

Intermediate filaments (IF) are a diverse family of cytoskeletal proteins which constitute flexible, rod-shaped fibers. IF networks integrate and organize the cytoplasm, providing mechanical integrity essential for proper function. They maintain cell shape, plasticity, elasticity, organize cells into tissues, and provide a scaffold for intracellular components and the plasma membrane where it interacts with extracellular environment. 

Phosphorylation-Induced Mechanical Regulation of Intrinsically Disordered Neurofilament Proteins

Congratulation to Eti, Micha and the rest of team for the wonderful work published in Biophysical Journal including an astonishing superhero cover! In the paper we show how phosphorylation manipulate neurofilament mechanics and macroscopic order. 

 

Dr. Roy Beck-Barkai | Tel Aviv University, Tel Aviv 69978, Israel | Office: Shenkar physics building, room 418 | Phone: +972-3-6408477, +972-3-6406896 | Email: This email address is being protected from spambots. You need JavaScript enabled to view it.This email address is being protected from spambots. You need JavaScript enabled to view it.">